Obtain serum lithium concentration assay after 3 days, drawn 12 hours after
Lithium Toxicity
Lithium drug interactions
Carbamazepine (with losartan only): Major interaction [reduced levels and efficacy of losartan via CYP3A4 induction] ADVICE: Consider another mood Most risk factors for developing lithium toxicity involve changes in sodium levels or the way the patient's body handles sodium
Drug interactions, such as that which occurred in this patient, are the most important cause of serious lithium toxicity
Combination therapy with both may be considered in clinical practice on occurrence of arterial A significantly reduced GCS or seizures in the context of lithium toxicity carries a significant risk of permanent neurological sequelae
Patients who are on long-term lithium therapy can develop localized edema, dermatitis, and skin ulcers
Severe lithium toxicity can lead to impaired consciousness, seizures, coma, and death
When reading the active ingredients list on non-prescription medications or when in doubt about any drug interaction, ask your pharmacist! Despite its virtually universal acceptance as the gold standard in treating bipolar disorder, prescription rates for lithium have been decreasing recently
She had a history of falls, bipolar disorder and type 2 diabetes mellitus
Clinicians need to be aware of potential lithium—ARB interactions resulting in an increased risk of lithium toxicity associated with concurrent use of these drugs
Lithium